EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.

@article{Shapira2017EBF2TR,
  title={EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.},
  author={Suzanne N. Shapira and H. Lim and S. Rajakumari and Alexander P. Sakers and Jeff Ishibashi and M. Harms and K. Won and P. Seale},
  journal={Genes & development},
  year={2017},
  volume={31 7},
  pages={
          660-673
        }
}
  • Suzanne N. Shapira, H. Lim, +5 authors P. Seale
  • Published 2017
  • Biology, Medicine
  • Genes & development
  • The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the mechanisms by which EBF2 regulates chromatin to activate brown fat-specific genes in adipocytes were unknown. ChIP-seq (chromatin immunoprecipitation [ChIP] followed by deep sequencing) analyses in brown adipose tissue showed that EBF2 binds and regulates the activity of lineage-specific enhancers. Mechanistically, EBF2 physically interacts with… CONTINUE READING
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    References

    SHOWING 1-10 OF 52 REFERENCES
    EBF2 determines and maintains brown adipocyte identity.
    • 247
    • PDF
    Opposing effects of SWI/SNF and Mi-2/NuRD chromatin remodeling complexes on epigenetic reprogramming by EBF and Pax5
    • 117
    • PDF
    Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex.
    • 178
    • Highly Influential
    • PDF
    Pioneering Activity of the C-Terminal Domain of EBF1 Shapes the Chromatin Landscape for B Cell Programming.
    • 55
    Baf60c is essential for function of BAF chromatin remodelling complexes in heart development
    • 459
    • PDF
    An Evi1-C/EBPβ Complex Controls Peroxisome Proliferator-Activated Receptor γ2 Gene Expression To Initiate White Fat Cell Differentiation
    • 30
    • PDF
    JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis
    • 62
    • Highly Influential
    • PDF
    PRDM16 controls a brown fat/skeletal muscle switch
    • 1,808
    • PDF