EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.

Suzanne N. Shapira; H. Lim; S. Rajakumari; Alexander P. Sakers; Jeff Ishibashi; M. Harms; K. Won; P. Seale

DOI:10.1101/gad.294405.116

Corpus ID: 206231105

EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.

@article{Shapira2017EBF2TR,
  title={EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex.},
  author={Suzanne N. Shapira and H. Lim and S. Rajakumari and Alexander P. Sakers and Jeff Ishibashi and M. Harms and K. Won and P. Seale},
  journal={Genes & development},
  year={2017},
  volume={31 7},
  pages={
          660-673
        }
}

Suzanne N. Shapira, H. Lim, +5 authors P. Seale

Published 2017

Biology, Medicine

Genes & development

The transcription factor early B-cell factor 2 (EBF2) is an essential mediator of brown adipocyte commitment and terminal differentiation. However, the mechanisms by which EBF2 regulates chromatin to activate brown fat-specific genes in adipocytes were unknown. ChIP-seq (chromatin immunoprecipitation [ChIP] followed by deep sequencing) analyses in brown adipose tissue showed that EBF2 binds and regulates the activity of lineage-specific enhancers. Mechanistically, EBF2 physically interacts with… CONTINUE READING

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