EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms.

@article{Schrder2011EB1AE,
  title={EB1 and EB3 promote cilia biogenesis by several centrosome-related mechanisms.},
  author={Jacob Morville Schr\oder and Jesper Larsen and Yulia Komarova and Anna Akhmanova and Rikke I Thorsteinsson and Ilya Grigoriev and Robert Manguso and S\oren Tvorup Christensen and Stine Falsig Pedersen and Stefan Geimer and Lotte B. Pedersen},
  journal={Journal of cell science},
  year={2011},
  volume={124 Pt 15},
  pages={2539-51}
}
The microtubule (MT) plus-end-tracking protein EB1 is required for assembly of primary cilia in mouse fibroblasts, but the mechanisms involved and the roles of the related proteins EB2 and EB3 in ciliogenesis are unknown. Using protein depletion experiments and expression of dominant-negative constructs we show here that EB1 and EB3, but not EB2, are required for assembly of primary cilia in cultured cells. Electron microscopy and live imaging showed that cells lacking EB1 or EB3 are defective… CONTINUE READING
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