EAK-7 controls development and life span by regulating nuclear DAF-16/FoxO activity.

Abstract

FoxO transcription factors control development and longevity in diverse species. Although FoxO regulation via changes in its subcellular localization is well established, little is known about how FoxO activity is regulated in the nucleus. Here, we show that the conserved C. elegans protein EAK-7 acts in parallel to the serine/threonine kinase AKT-1 to… (More)
DOI: 10.1016/j.cmet.2010.05.004

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