EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate

@inproceedings{Pascal2011EAF2LE,
  title={EAF2 loss enhances angiogenic effects of Von Hippel-Lindau heterozygosity on the murine liver and prostate},
  author={Laura E Pascal and Junkui Ai and Lora H. Rigatti and Anne K. Lipton and Wuhan Xiao and James R. Gnarra and Zhou Bi Wang},
  booktitle={Angiogenesis},
  year={2011}
}
Von Hippel-Lindau (VHL) disease results from the inactivation of the VHL gene and is characterized by highly vascular tumors. A consequence of VHL loss is the stabilization of hypoxia-inducible factor (HIF) alpha subunits and increased expression of HIF target genes, which include pro-angiogenic growth factors such as vascular endothelial growth factor… CONTINUE READING