EADock: docking of small molecules into protein active sites with a multiobjective evolutionary optimization.

@article{Grosdidier2007EADockDO,
  title={EADock: docking of small molecules into protein active sites with a multiobjective evolutionary optimization.},
  author={Aur{\'e}lien Grosdidier and Vincent Zoete and Olivier Michielin},
  journal={Proteins},
  year={2007},
  volume={67 4},
  pages={1010-25}
}
In recent years, protein-ligand docking has become a powerful tool for drug development. Although several approaches suitable for high throughput screening are available, there is a need for methods able to identify binding modes with high accuracy. This accuracy is essential to reliably compute the binding free energy of the ligand. Such methods are needed when the binding mode of lead compounds is not determined experimentally but is needed for structure-based lead optimization. We present… CONTINUE READING

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