E6a2 BCR-ABL fusion with BCR exon 5-deleted transcript in a Philadelphia positive CML responsive to Imatinib.

@article{Popovici2005E6a2BF,
  title={E6a2 BCR-ABL fusion with BCR exon 5-deleted transcript in a Philadelphia positive CML responsive to Imatinib.},
  author={Cornel Popovici and Sylvie Cailleres and Martine David and Marina Lafage-Pochitaloff and Danielle Sainty and M J Mozziconacci},
  journal={Leukemia & lymphoma},
  year={2005},
  volume={46 9},
  pages={1375-7}
}
Chronic myeloid leukemia (CML) is characterized in 90% of patients by the presence of the reciprocal translocation t(9;22)(q34;q11) leading to the fusion of the BCR and ABL genes. Most patients with Philadelphia chromosome positive CML express either the e13a2 (b2a2) or e14a2 (b3a2) MBCR-ABL mRNA. Some variant cases have been reported expressing the fusion e1a2 (mBCR-ABL) or e19a2 (microBCR-ABL). Very rare atypical transcripts such as e13a3, e14a3 or e6a2 have been described. We report here a… CONTINUE READING

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