E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain.

@article{Ashrafi2006E5PO,
  title={E5 protein of human papillomavirus 16 downregulates HLA class I and interacts with the heavy chain via its first hydrophobic domain.},
  author={G. Hossein Ashrafi and Mohammad Reza Haghshenas and Barbara Marchetti and Maria Saveria Campo},
  journal={International journal of cancer},
  year={2006},
  volume={119 9},
  pages={2105-12}
}
Human papillomavirus type 16 E5 protein (HPV-16 E5) is expressed early in papillomavirus infection and is localised primarily in the cell Golgi apparatus (GA) and endoplasmic reticulum. E5 prevents transport of the major histocompatibility class I (MHC I; HLA class I in humans) to the cell surface and retains the complex in the GA. We report that these effects are due, at least in part, to the interaction between E5 and HLA I heavy chain (HC). We also demonstrate that the down-regulation of… CONTINUE READING
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Biological Activities of Papillomavirus E5 Proteins

  • FA Suprynowicz, M. S. Campo, R. Schlegel
  • 2006

Human Immunodeficiency Virus Type 1 Nef domains required for disruption of Major Histocompatibility Complex Class I trafficking are also necessary for coprecipitation of Nef with HLA-A2

  • M Williams, F RoethJ, MR Kasper, TM Filzen, KL Collins
  • J. Virol
  • 2005

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