E4orf1 Improves Lipid and Glucose Metabolism in Hepatocytes: A Template to Improve Steatosis & Hyperglycemia

@inproceedings{Dhurandhar2012E4orf1IL,
  title={E4orf1 Improves Lipid and Glucose Metabolism in Hepatocytes: A Template to Improve Steatosis & Hyperglycemia},
  author={Emily J Dhurandhar and Rashmi Krishnapuram and Vijay Hegde and Olga S Dubuisson and Rongya Tao and X Charlie Dong and Jianping Ye and Nikhil V Dhurandhar},
  booktitle={PloS one},
  year={2012}
}
Hepatic steatosis often accompanies obesity and insulin resistance. The cornerstones of steatosis treatment include reducing body weight and dietary fat intake, which are marginally successful over the long term. Ad36, a human adenovirus, may offer a template to overcome these limitations. In vitro and in vivo studies collectively indicate that via its E4orf1 protein, Ad36 improves hyperglycemia, and attenuates hepatic steatosis, despite a high fat diet and without weight loss. Considering that… CONTINUE READING
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