E355G mutation appearing in a patient with e19a2 chronic myeloid leukaemia resistant to imatinib.

@article{Bennour2010E355GMA,
  title={E355G mutation appearing in a patient with e19a2 chronic myeloid leukaemia resistant to imatinib.},
  author={Ayda Bennour and Nathalie Beaufils and Halima Sennana and Balkis Meddeb and Ali Kandil Saad and Jean Gabert},
  journal={Journal of clinical pathology},
  year={2010},
  volume={63 8},
  pages={
          737-40
        }
}
The development of imatinib is a milestone in the treatment of chronic myeloid leukaemia (CML), and its therapeutic effect has been extensively investigated in patients with CML who carry M-bcr and m-bcr BCR-ABL fusion transcripts. However, knowledge about its therapeutic effect on patients with CML who have the rare BCR-ABL fusion transcript e19a2 (mu-bcr) remains sparse. This report describes a patient with Philadelphia-positive chronic myeloid leukaemia with e19a2 rearrangement, in whom… CONTINUE READING