E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.


Wnt signaling, named after the secreted proteins that bind to cell surface receptors to activate the pathway, plays critical roles both in embryonic development and the maintenance of homeostasis in many adult tissues. Two particularly important cellular programs orchestrated by Wnt signaling are proliferation and stem cell self-renewal. Constitutive… (More)
DOI: 10.1073/pnas.1621355114


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