E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models

@article{Wang2003E3GM,
  title={E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models},
  author={Yaohe Wang and Gunnel K. Hallden and Richard O. Hill and Arthi Anand and Ta-Chiang Liu and Jennelle Francis and Gabriel T. Brooks and Nicholas R. Lemoine and David H. Kirn},
  journal={Nature Biotechnology},
  year={2003},
  volume={21},
  pages={1328-1335}
}
Oncolytic replication-selective adenoviruses constitute a rapidly growing therapeutic platform for cancer. However, the role of the host immune response and the E3 immunoregulatory genes of the human adenovirus were unknown until now. We identified four mouse carcinoma lines of variable permissivity for adenoviral gene expression, cytopathic effects and/or burst size. To determine E3 gene effects in immunocompetent tumor-bearing hosts, we injected tumors with one of three adenoviruses: Ad5 (E3… CONTINUE READING
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