E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha

@inproceedings{Pal2013E3UL,
  title={E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha},
  author={Pooja Pal and Savita Lochab and Jitendra Kumar Kanaujiya and Isha Kapoor and Sabyasachi Sanyal and Gerhard Behre and Arun Kumar Trivedi},
  booktitle={PloS one},
  year={2013}
}
CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for the first time we demonstrate that E6AP, an E3 ubiquitin ligase inhibits adipocyte differentiation in 3T3-L1 cells as revealed by reduced lipid staining with oil red. Knock down of E6AP in mouse 3T3L1 preadipocytes is sufficient to convert them to adipocytes independent of external hormonal induction. C/EBPα protein level is drastically increased in E6AP deficient… CONTINUE READING
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E 6 AP , an E 3 ubiquitin ligase negatively regulates granulopoiesis by targeting transcription factor C / EBPa for ubiquitinmediated Q 1 proteasome degradation

  • L Subramanian, Benson, JA Iniguez-Lluhi
  • Cell Death and Disease
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