E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation.

@article{Kinross2006E2f4RF,
  title={E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation.},
  author={Kathryn M. Kinross and Allison J. Clark and Rosa M. Iazzolino and Patrick O. Humbert},
  journal={Blood},
  year={2006},
  volume={108 3},
  pages={
          886-95
        }
}
The E2F proteins are major regulators of the transcriptional program required to coordinate cell cycle progression and exit. In particular, E2f4 has been proposed to be the principal family member responsible for the regulation of cell cycle exit chiefly through its transcriptional repressive properties. We have previously shown that E2f4(-/-) mice display a marked macrocytic anemia implicating E2f4 in the regulation of erythropoiesis. However, these studies could not distinguish whether E2f4… 
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