E2F6: a member of the E2F family that does not modulate squamous differentiation.

@article{Wong2004E2F6AM,
  title={E2F6: a member of the E2F family that does not modulate squamous differentiation.},
  author={Chung Fai Wong and Liam M Barnes and Louise Lawson Smith and Claudia Popa and Magdalena M M Serewko-Auret and Nicholas A Saunders},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={324 2},
  pages={497-503}
}
The inhibition of E2F has been demonstrated to be important in the initiation of squamous differentiation by two independent manners: promotion of growth arrest and the relief of the differentiation-suppressive properties of E2Fs. E2F6 is reported to behave as a transcriptional repressor of the E2F family. In this study, we examined the ability of E2F6 to act as the molecular switch required for E2F inhibition in order for keratinocytes to enter a terminal differentiation programme. Results… CONTINUE READING