E2F4 is required for cardiomyocyte proliferation.

@article{vanAmerongen2010E2F4IR,
  title={E2F4 is required for cardiomyocyte proliferation.},
  author={Machteld J. van Amerongen and Florian Diehl and Tatyana Novoyatleva and Chinmoy Patra and Felix B. Engel},
  journal={Cardiovascular research},
  year={2010},
  volume={86 1},
  pages={
          92-102
        }
}
AIMS Although the fundamental role of the E2F transcription factor family in cell proliferation is well established, the specific function of E2F4 is unclear. On the basis of findings from cell culture experiments, E2F4 is generally considered as an inhibitor of cell proliferation. Accumulating evidence suggests, however, that E2F4 acts as an activator of cell proliferation in certain contexts. Here, we have investigated the role of E2F4 during heart development and in proliferating… 
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TLDR
The current understanding of the E2F pathway and its contribution to normal and pathological cardiac development and growth is summarized.
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The activities of E1F proteins in cancer and therapeutic strategies to target this oncogenic pathway are discussed, with an emphasis on the newest atypical E2F family members.
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The notion that it is possible to reprogramme cardiomyocytes into a regenerative state and that this property can be enhanced by non-coding RNA therapeutics remains exciting, however extensive experimentation in large mammals and rigorous assessment of safety are required to advance towards clinical application.
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