E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.

@article{Garneau2009E2F4EI,
  title={E2F4 expression is required for cell cycle progression of normal intestinal crypt cells and colorectal cancer cells.},
  author={Hugo Garneau and Marie-Christine Paquin and Julie C. Carrier and N. Rivard},
  journal={Journal of cellular physiology},
  year={2009},
  volume={221 2},
  pages={350-8}
}
The generation of knock-out mice for E2F4 gene expression has suggested a role for this transcription factor in establishing and/or maintaining the intestinal crypt compartment. Having previously demonstrated that E2F4 is cytoplasmic in quiescent-differentiated cells but nuclear in growth factor-stimulated proliferative cells, the present study was aimed at… CONTINUE READING