E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair.

@article{Chen2008E2F1RT,
  title={E2F1 regulates the base excision repair gene XRCC1 and promotes DNA repair.},
  author={Dexi X Chen and Zhiyong Yu and Zhiyi Zhu and Charles Darin Lopez},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 22},
  pages={
          15381-9
        }
}
The E2F1 transcription factor activates S-phase-promoting genes, mediates apoptosis, and stimulates DNA repair through incompletely understood mechanisms. XRCC1 (x-ray repair cross-complementing group 1) protein is important for efficient single strand break/base excision repair. Although both damage and proliferative signals increase XRCC1 levels, the mechanisms regulating XRCC1 transcription remain unclear. To study these upstream mechanisms, the XRCC1 promoter was cloned into a luciferase… CONTINUE READING

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