E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry

@inproceedings{Alla2012E2F1CA,
  title={E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry},
  author={Vijay Alla and Bhavani S. Kowtharapu and David Engelmann and Stephan Emmrich and Ulf Schmitz and Marc Steder and Brigitte M. P{\"u}tzer},
  booktitle={Cell cycle},
  year={2012}
}
Resistance to anti-neoplastic agents is the major cause of therapy failure, leading to disease recurrence and metastasis. E2F1 is a strong inducer of apoptosis in response to DNA damage through its capacity to activate p53/p73 death pathways. Recent evidence, however, showed that E2F1, which is aberrantly expressed in advanced malignant melanomas together with antagonistic p73 family members, drives cancer progression. Investigating mechanisms responsible for dysregulated E2F1 losing its… CONTINUE READING

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