E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation.

@article{Yang2011E2F1AR,
  title={E2F1 and RNA binding protein QKI comprise a negative feedback in the cell cycle regulation.},
  author={Guodong Yang and Xiaozhao Lu and Li Wang and Yongqian Bian and Haiyan Fu and Mengying Wei and Jun Pu and Liang Jin and Li-bo Yao and Zi-fan Lu},
  journal={Cell cycle},
  year={2011},
  volume={10 16},
  pages={2703-13}
}
pRb/E2F1 activity is coordinately regulated during the cell cycle progression, while the molecular strategies safeguarding this pathway are not fully understood. We have previously shown that RNA binding protein QKI inhibits the cell proliferation and promotes the differentiation of gastrointestinal epithelium, suggesting a role of QKI in cell cycle regulation. Here we found that with the cell entry into S phase, QKI expression increased both at the mRNA and protein levels, which was… CONTINUE READING

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