E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.

@article{Zhu2001E2F1AE,
  title={E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis.},
  author={Jing W. Zhu and Seth J. Field and Lia Gore and Margaret Thompson and Hongbo Yang and Yuko Fujiwara and Robert Cardiff and Melody Greenberg and Stuart H Orkin and James V Degregori},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 24},
  pages={8547-64}
}
E2F activity is critical for the control of the G(1) to S phase transition. We show that the combined loss of E2F1 and E2F2 results in profound effects on hematopoietic cell proliferation and differentiation, as well as increased tumorigenesis and decreased lymphocyte tolerance. The loss of E2F1 and E2F2 impedes B-cell differentiation, and hematopoietic… CONTINUE READING