E2F transcription factors and digestive system malignancies: how much do we know?

@article{Xanthoulis2013E2FTF,
  title={E2F transcription factors and digestive system malignancies: how much do we know?},
  author={Athanasios Xanthoulis and Dina G. Tiniakos},
  journal={World journal of gastroenterology},
  year={2013},
  volume={19 21},
  pages={3189-98}
}
E2F family of transcription factors regulates various cellular functions related to cell cycle and apoptosis. Its individual members have traditionally been classified into activators and repressors, based on in vitro studies. However their contribution in human cancer is more complicated and difficult to predict. We review current knowledge on the expression of E2Fs in digestive system malignancies and its clinical implications for patient prognosis and treatment. E2F1, the most extensively… CONTINUE READING