E2F transcription factor-1 regulates oxidative metabolism

  title={E2F transcription factor-1 regulates oxidative metabolism},
  author={Emilie Blanchet and J S Annicotte and Sylviane Lagarrigue and Victor Aguilar and Cyrielle Clap{\'e} and Carine Chavey and Vanessa Fritz and François Casas and Florence Apparailly and Johan Auwerx and Lluis Fajas},
  journal={Nature Cell Biology},
Cells respond to stress by coordinating proliferative and metabolic pathways. Starvation restricts cell proliferative (glycolytic) and activates energy productive (oxidative) pathways. Conversely, cell growth and proliferation require increased glycolytic and decreased oxidative metabolism levels. E2F transcription factors regulate both proliferative and metabolic genes. E2Fs have been implicated in the G1/S cell-cycle transition, DNA repair, apoptosis, development and differentiation. In… CONTINUE READING
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