E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism

Abstract

E2F1 deletion leads to increased mitochondrial number and function, increased body temperature in response to cold and increased resistance to fatigue with exercise. Since E2f1-/- mice show increased muscle performance, we examined the effect of E2f1 genetic inactivation in the mdx background, a mouse model of Duchenne muscular dystrophy (DMD). E2f1-/-;mdx… (More)
DOI: 10.1093/hmg/dds219

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@inproceedings{Blanchet2012E2FTF, title={E2F transcription factor-1 deficiency reduces pathophysiology in the mouse model of Duchenne muscular dystrophy through increased muscle oxidative metabolism}, author={{\'E}milie Blanchet and Jean-S{\'e}bastien Annicotte and Ludivine A. Pradelli and G{\'e}rald Hugon and Stefan Matecki and Dominique Mornet and François Rivier and Lluis Fajas}, booktitle={Human molecular genetics}, year={2012} }