E2F target genes: unraveling the biology.

@article{Bracken2004E2FTG,
  title={E2F target genes: unraveling the biology.},
  author={Adrian P Bracken and Marco Cir{\'o} and Andrea Cocito and Kristian Helin},
  journal={Trends in biochemical sciences},
  year={2004},
  volume={29 8},
  pages={
          409-17
        }
}
The E2F transcription factors are downstream effectors of the retinoblastoma protein (pRB) pathway and are required for the timely regulation of numerous genes essential for DNA replication and cell cycle progression. Several laboratories have used genome-wide approaches to discover novel target genes of E2F, leading to the identification of several hundred such genes that are involved not only in DNA replication and cell cycle progression, but also in DNA damage repair, apoptosis… CONTINUE READING
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