E2F activity is regulated by cell cycle-dependent changes in subcellular localization.

@article{Verona1997E2FAI,
  title={E2F activity is regulated by cell cycle-dependent changes in subcellular localization.},
  author={Raluca Verona and Kirk D. Moberg and Scott Estes and M A Starz and J P Vernon and Jacqueline A Lees},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 12},
  pages={7268-82}
}
E2F directs the cell cycle-dependent expression of genes that induce or regulate the cell division process. In mammalian cells, this transcriptional activity arises from the combined properties of multiple E2F-DP heterodimers. In this study, we show that the transcriptional potential of individual E2F species is dependent upon their nuclear localization. This is a constitutive property of E2F-1, -2, and -3, whereas the nuclear localization of E2F-4 is dependent upon its association with other… CONTINUE READING

From This Paper

Topics from this paper.
81 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 81 extracted citations

Similar Papers

Loading similar papers…