E2F activators signal and maintain centrosome amplification in breast cancer cells.

Abstract

Centrosomes ensure accurate chromosome segregation by directing spindle bipolarity. Loss of centrosome regulation results in centrosome amplification, multipolar mitosis and aneuploidy. Since centrosome amplification is common in premalignant lesions and breast tumors, it is proposed to play a central role in breast tumorigenesis, a hypothesis that remains… (More)

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Cite this paper

@article{Lee2014E2FAS, title={E2F activators signal and maintain centrosome amplification in breast cancer cells.}, author={Mi-Young Lee and Carlos S. Moreno and Harold I. Saavedra}, journal={Molecular and cellular biology}, year={2014}, volume={34 14}, pages={2581-99} }