E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.

@article{Tyagi2007E2FAO,
  title={E2F activation of S phase promoters via association with HCF-1 and the MLL family of histone H3K4 methyltransferases.},
  author={Shweta Tyagi and Anna Lena Chabes and Joanna Wysocka and Winship Herr},
  journal={Molecular cell},
  year={2007},
  volume={27 1},
  pages={107-19}
}
E2F transcriptional regulators control human-cell proliferation by repressing and activating the transcription of genes required for cell-cycle progression, particularly the S phase. E2F proteins repress transcription in association with retinoblastoma pocket proteins, but less is known about how they activate transcription. Here, we show that the human G1 phase regulator HCF-1 associates with both activator (E2F1 and E2F3a) and repressor (E2F4) E2F proteins, properties that are conserved in… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS