E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells.


Although overexpression of E2F-1 can induce apoptosis in a variety of tumor cell lines, the mechanisms by which E2F-1 induces apoptosis remain ambiguous. In this study, we examine the ability of E2F-1 to induce apoptosis in colon cancer and the molecular mechanisms underlying E2F-1-mediated apoptosis. HT-29 and SW-620 colon adenocarcinoma cells (both mutant… (More)


8 Figures and Tables

Slides referencing similar topics