E2F-1 is a critical modulator of cellular senescence in human cancer.

@article{Park2006E2F1IA,
  title={E2F-1 is a critical modulator of cellular senescence in human cancer.},
  author={Chaehwa Park and Inkyoung Lee and Won Ki Kang},
  journal={International journal of molecular medicine},
  year={2006},
  volume={17 5},
  pages={715-20}
}
Senescence limits cellular proliferation, and therefore might be a mechanism which could suppress the progression of cancer. Herein we show that E2F1, a transcription factor essential to a cell cycle progress and a main target of tumor suppressor Rb, is a critical barrier for the induction of senescence. Human cancer cells transfected with siE2F1 were shown to express replicative senescence markers, in addition to yielding positive results upon SA-beta-Gal staining. Consistent with the notion… CONTINUE READING