E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.

Abstract

The E2F DNA binding activity consists of a heterodimer between E2F and DP family proteins, and these interactions are required for association of E2F proteins with pRb and the pRb-related proteins p107 and p130, which modulate E2F transcriptional activities. E2F-1 expression is sufficient to release fibroblasts from G0 and induce entry into S phase, yet it… (More)

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Cite this paper

@article{Hiebert1995E2F1DP1IP, title={E2F-1:DP-1 induces p53 and overrides survival factors to trigger apoptosis.}, author={Scott W. Hiebert and G. Packham and David K Strom and Rebecca Haffner and Moshe Oren and Gerard P. Zambetti and John L. Cleveland}, journal={Molecular and cellular biology}, year={1995}, volume={15 12}, pages={6864-74} }