E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.

@article{Nevins1992E2FAL,
  title={E2F: a link between the Rb tumor suppressor protein and viral oncoproteins.},
  author={J. R. Nevins},
  journal={Science},
  year={1992},
  volume={258 5081},
  pages={424-9}
}
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common… CONTINUE READING
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