E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.

@article{Semerad2009E2APM,
  title={E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.},
  author={Craig L Semerad and Elinore M Mercer and Matthew A Inlay and Irving L Weissman and Cornelis Murre},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 6},
  pages={1930-5}
}
Hematopoiesis is a tightly controlled process maintained by a small pool of hematopoietic stem cells (HSCs). Here, we demonstrate that the LT-HSC, MPP, premegakaryocytic/erythroid, Pre CFU-E, Pre GM, MkP, and granulocyte-macrophage compartments were all significantly reduced in E2A-deficient bone marrow. Despite a severe depletion of erythroid progenitors, the erythrocyte and megakaryocyte compartments were equivalent in E2A-deficient bone marrow as compared with wild-type mice. E2A-deficient… CONTINUE READING

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