E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination.

@article{Quong1999E2AAI,
  title={E2A activity is induced during B-cell activation to promote immunoglobulin class switch recombination.},
  author={Melanie W. Quong and David P. Harris and Suzy L. Swain and Cornelis Murre},
  journal={The EMBO journal},
  year={1999},
  volume={18 22},
  pages={6307-18}
}
The basic helix-loop-helix protein, E2A, is required for proper early B lymphopoiesis. Specifically, in E2A-deficient mice, B-cell development is blocked at the progenitor stage prior to the onset of immunoglobulin (Ig) V(D)J recombination. Here, we demonstrate that E2A plays an additional role during peripheral B lymphopoiesis. Upon activation of primary mature B lymphocytes, both E2A protein levels and DNA-binding activity are induced. Furthermore, we show that mature B cells, expressing a… CONTINUE READING

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