E2A-HLF usurps control of evolutionarily conserved survival pathways


E2A-HLF, the chimeric fusion protein resulting from the leukemogenic translocation t(17;19), appears to employ evolutionarily conserved signaling cascades for its transforming and antiapoptotic functions. These arise from both impairment of normal E2A function and activation of a survival pathway triggered through the HLF bZip DNA binding and dimerization… (More)
DOI: 10.1038/sj.onc.1204591


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