E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: effect on cross-bridge kinetics.

@article{Dumka2006E22KMO,
  title={E22K mutation of RLC that causes familial hypertrophic cardiomyopathy in heterozygous mouse myocardium: effect on cross-bridge kinetics.},
  author={D. Dumka and Jim Talent and Irina Akopova and Gast{\'o}n Guzm{\'a}n and Danuta Szczesna-Cordary and Julian Borejdo},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2006},
  volume={291 5},
  pages={H2098-106}
}
Familial hypertrophic cardiomyopathy is a disease characterized by left ventricular and/or septal hypertrophy and myofibrillar disarray. It is caused by mutations in sarcomeric proteins, including the ventricular isoform of myosin regulatory light chain (RLC). The E22K mutation is located in the RLC Ca(2+)-binding site. We have studied transgenic (Tg) mouse cardiac myofibrils during single-turnover contraction to examine the influence of E22K mutation on 1) dissociation time (tau(1)) of myosin… CONTINUE READING
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