E1k, another quantitative variant at cholinesterase locus 1.

  title={E1k, another quantitative variant at cholinesterase locus 1.},
  author={Herbert M. Rubinstein and A A Dietz and Tina Lubrano},
  journal={Journal of medical genetics},
  volume={15 1},
Two families segregating for the atypical (E1a) allele at cholinesterase locus 1 are described. Unusual results for dibucaine inhibition led to the recognition of a new allele (E1k) also segregating in these families. The enzymatic and immunological data are consistent with the hypothesis that E1k causes reduction of 'usual' (E1u) molecules by about 33%. Whether the reduction of E1u caused by E1k is caused by retarded synthesis or accelerated degradation of serum cholinesterase remains to be… CONTINUE READING

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