E1B55K-deleted adenovirus (ONYX-015) overrides G1/S and G2/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells.

@article{Cherubini2006E1B55KdeletedA,
  title={E1B55K-deleted adenovirus (ONYX-015) overrides G1/S and G2/M checkpoints and causes mitotic catastrophe and endoreduplication in p53-proficient normal cells.},
  author={Gioia Cherubini and Tatiana Petouchoff and M. D. Grossi and Stefania Piersanti and Enrico Cundari and Isabella Saggio},
  journal={Cell cycle},
  year={2006},
  volume={5 19},
  pages={2244-52}
}
In order to take advantage of cell replication machinery, viruses have evolved complex strategies to override cell cycle checkpoints and force host cells into S phase. To do so, virus products must interfere not only with the basal cell cycle regulators, such as pRb or Mad2, but also with the main surveillance pathways such as those controlled by p53 and ATM. Recently, a number of defective viruses has been produced which, lacking the latter ability, are incapable of replicating in normal cells… CONTINUE READING
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