E1A signaling to p53 involves the p19(ARF) tumor suppressor.

@article{Stanchina1998E1AST,
  title={E1A signaling to p53 involves the p19(ARF) tumor suppressor.},
  author={Elisa de Stanchina and Mila E. McCurrach and Fr{\'e}d{\'e}rique Zindy and S Y Shieh and Gerardo Ferbeyre and Andrew V Samuelson and Carol Prives and Martine F Roussel and Charles J Sherr and Scott W Lowe},
  journal={Genes & development},
  year={1998},
  volume={12 15},
  pages={
          2434-42
        }
}
The adenovirus E1A oncogene activates p53 through a signaling pathway involving the retinoblastoma protein and the tumor suppressor p19(ARF). The ability of E1A to induce p53 and its transcriptional targets is severely compromised in ARF-null cells, which remain resistant to apoptosis following serum depletion or adriamycin treatment. Reintroduction of p19(ARF) restores p53 accumulation and resensitizes ARF-null cells to apoptotic signals. Therefore, p19(ARF) functions as part of a p53… CONTINUE READING

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