E1A directly binds and regulates the P/CAF acetyltransferase.

  title={E1A directly binds and regulates the P/CAF acetyltransferase.},
  author={Juliet L. Reid and Andrew J. Bannister and Philip Zegerman and Marian A Mart{\'i}nez-Balb{\'a}s and Tony Kouzarides},
  journal={The EMBO journal},
  volume={17 15},
The P/CAF protein has intrinsic histone acetyltransferase (HAT) activity and is capable of binding the transcriptional co-activator CBP. Here we show that P/CAF can regulate transcription and that this function is independent of its binding to CBP. The HAT domain of P/CAF has transcriptional activation potential in yeast. In mammalian cells P/CAF can stimulate transcription of the RSV promoter, using the activity of its HAT domain. We show that the adenovirus protein E1A targets P/CAF and… CONTINUE READING