E1 protein of bovine papillomavirus 1 is not required for the maintenance of viral plasmid DNA replication.

@article{Kim2002E1PO,
  title={E1 protein of bovine papillomavirus 1 is not required for the maintenance of viral plasmid DNA replication.},
  author={Kitai Kim and Paul F. Lambert},
  journal={Virology},
  year={2002},
  volume={293 1},
  pages={10-4}
}
Derivatives of bovine papillomavirus 1 (BPV1) with temperature-sensitive and dominant-negative mutation the E1 gene were used to determine the requirement for E1 in the maintenance of viral plasmid DNA replication. The abilities of these mutant BPV1 genomes to replicate as nuclear plasmids were monitored at permissive (32 degrees C) and nonpermissive (37 degrees C) temperatures in mouse C127 cells. We found that the temperature-sensitive E1 mutant BPV1 genomes replicate as nuclear plasmids as… CONTINUE READING

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