Corpus ID: 16683074

E. B. Lewis and the bithorax complex: part II. From cis-trans test to the genetic control of development.

@article{Duncan2002EBL,
  title={E. B. Lewis and the bithorax complex: part II. From cis-trans test to the genetic control of development.},
  author={Ian Duncan and Geoffrey Montgomery},
  journal={Genetics},
  year={2002},
  volume={161 1},
  pages={
          1-10
        }
}
AS discussed in Part I of this Perspectives (see the April issue of Genetics), E. B. Lewis’s early studies of the BX-C revealed a series of five bithorax complex (BX-C) “pseudoalleles” separable by recombination and by function, with the map order: bx Cbx Ubx bxd pbx . Lewis found pronounced 
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References

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TLDR
The bithorax complex (BX-C), a gene cluster that controls the identities of body segments in the abdomen and posterior thorax of Drosophila, is described. Expand
Genetic organization of Drosophila bithorax complex
The Drosophila bithorax complex is subdivided into three major genes: Ultrabithorax+, abdominal-A+ and Abdominal-B+. Each of these genes plays its principal part in a particular anatomical domain ofExpand
Complete sequence of the bithorax complex of Drosophila.
TLDR
The strategy used in sequencing SEQ89E and an analysis of its open reading frames are presented and principal findings include a putative ABD-A protein larger than a previously known ABD -A protein and aPutative glucose transporter-like gene located at or near the bithoraxoid (bxd), infra-abdominal-2 (iab-2) boundary on the opposite strand relative to that of the homeobox-containing genes. Expand
The abdominal region of the bithorax complex
TLDR
A chromosomal walk in the bithorax complex of Drosophila has been extended 215 kb through the right half of the complex, and lesions for over 40 mutations have been located on the DNA map. Expand
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TLDR
The molecular and developmental analyses of the Antennapedia complex have shown that it differs from the Bithorax complex in two striking ways, in the spatial patterns of expression of the homeotic genes of the ANT-C that is necessary in the head. Expand
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TLDR
The DNA of the bithorax complex has been isolated, and a region of 195,000 base pairs that covers the left half of the complex is described here. Expand
Contrabithorax mutations cause inappropriate expression of Ultrabithorax products in Drosophila
TLDR
The suggestion that products of the BX-C were both necessary and sufficient to specify the unique developmental pathways of different segments strongly supports the suggestion that these products execute the functions of the proximal or Ultra-bithorax domain of the Haltere mimic trascription unit. Expand
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TLDR
Wild-type and mutant distributions of the segmental distributions and nuclear localization of proteins encoded by the Ubx unit have been determined by immunofluorescence staining with antibodies raised against a fusion protein containing Ubx coding sequences. Expand
Regulation of the distribution of Ultrabithorax proteins in Drosophila
TLDR
The results support the view that the Ubx proteins represent the executive functions of the UbX region5 and that the subfunction mutations affect regulatory regions required for the normal pattern of Ubx expression5,6 and show that the region of the BX-C containing the abd-A and Abd-B complementation groups regulates the distribution of UbX products. Expand
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes
A repetitive DNA sequence has been identified in the Drosophila melanogaster genome that appears to be localized specifically within genes of the bithorax and Antennapedia complexes that are requiredExpand
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