E-selectin can mediate the arrest type of adhesion of colon cancer cells under physiological shear flow.

@article{Kitayama2000EselectinCM,
  title={E-selectin can mediate the arrest type of adhesion of colon cancer cells under physiological shear flow.},
  author={Joji Kitayama and Nelson Hirokazu Tsuno and Eiji Sunami and Takuya Osada and Tetsuichiro Muto and Hirokazu Nagawa},
  journal={European journal of cancer},
  year={2000},
  volume={36 1},
  pages={
          121-7
        }
}
The aim of this study was to determine whether colon cancer cells flowing in blood exhibit the same adhesion pattern to the vascular bed as leucocytes using a flow adhesion system. In shear flow conditions, five colon cancer cell lines showed less tethering to E-selectin substrates than polymorphonuclear cells (PMN). However, some of the Colo201 cells formed complete arrest on E-selectin in continuous shear flow which was never observed in PMN cells. Colo201 cells expressed both sialyl Le-x and… CONTINUE READING
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