E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.

@article{Moeroey1991EMN,
  title={E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.},
  author={Tarik Moeroey and Sjef S Verbeek and A Ma and Philip L Achacoso and Anton Berns and Frederick W Alt},
  journal={Oncogene},
  year={1991},
  volume={6 11},
  pages={1941-8}
}
Transgenic mice that contain the L-myc gene under the control of the immunoglobulin heavy-chain enhancer (E mu) express the transgene preferentially in T cells, develop thymic hyperplasia and are predisposed to T-cell lymphomas. An analogous E mu N-myc transgene is expressed preferentially in pre-B and B cells and provokes the development of B-cell neoplasias. Animals with an E mu pim-1 construct express the transgene in both B and T cells, but succumb to T-cell lymphomas. Complementation of… CONTINUE READING

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