E ect of a specific endothelin receptor A antagonist and an angiotensin- converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis


attenuated the decreases in mRNA levels for HSPG (P<0.01) in glomeruli of PAN-injected rats. Enalapril Background. We previously reported that mRNA levels for extracellular matrix (ECM) components had little e ect on increased glomerular mRNA levels for MMP-2 and TIMP-1 in PAN nephrosis, whereas and endothelin (ET)-1 are upregulated in glomeruli of… (More)


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