E-cadherin transforms embryonic corneal fibroblasts to stratified epithelium with desmosomes.

@article{Vanderburg1996EcadherinTE,
  title={E-cadherin transforms embryonic corneal fibroblasts to stratified epithelium with desmosomes.},
  author={Charles R. Vanderburg and Elizabeth Dexter Hay},
  journal={Acta anatomica},
  year={1996},
  volume={157 2},
  pages={87-104}
}
Important and precisely regulated transitions in tissue phenotype from epithelium to mesenchyme and from mesenchyme to epithelium occur in the developing embryo. The gene for E-cadherin has been shown to cause fibroblastic cell lines to become epithelioid in culture. We asked whether or not the activities of the E-cadherin gene could cause a definitive embryonic mesenchyme to transdifferentiate into an epithelial phenotype. Primary corneal fibroblasts from 6- to 7-day-old chick embryos were… CONTINUE READING