E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.

  title={E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.},
  author={N Kim and Eunjin Koh and Xiao Chen and Barry Gumbiner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={108 29},
Contact inhibition of cell growth is essential for embryonic development and maintenance of tissue architecture in adult organisms, and the growth of tumors is characterized by a loss of contact inhibition of proliferation. The recently identified Hippo signaling pathway has been implicated in contact inhibition of proliferation as well as organ size control. The modulation of the phosphorylation and nuclear localization of Yes-associated protein (YAP) by the highly conserved kinase cascade of… CONTINUE READING
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