E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway.

@article{Day1999EcadherinMA,
  title={E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway.},
  author={Mark L. Day and Xiuhua Zhao and Christopher J. Vallorosi and Mathew J. Putzi and C. Thomas Powell and C Lin and Kathleen C. Day},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 14},
  pages={9656-64}
}
E-cadherin and the retinoblastoma tumor suppressor (Rb) are traditionally associated with diverse regulatory aspects of cell growth and differentiation. However, we have discovered new evidence, which suggests that these proteins are functionally linked in a physiologic pathway required for cell survival and programmed cell death. Pharmacological activation of protein kinase C (PKC) or inducible overexpression and activation of the alpha isozyme of PKC (PKCalpha) resulted in approximately 60… CONTINUE READING

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