E-cadherin mediates adherens junction organization through protein kinase C.

  title={E-cadherin mediates adherens junction organization through protein kinase C.},
  author={Jason E Lewis and Pamela J. Jensen and Keith R. Johnson and Margaret J. Wheelock},
  journal={Journal of cell science},
  volume={107 ( Pt 12)},
Cultured human keratinocytes maintained in 30 microM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C. 

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Protein kinase C regulates keratinocyte transglutaminase ( TG κ ) gene expression in cultured primary mouse epidermal keratinocytes to terminally differentiate by Ca 2 +

A. A. Dlugosz, S. H. Yupsa
J . Invest . Dermatol . • 1994

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