E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription.

@article{Torres2007EcadherinIR,
  title={E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription.},
  author={Vicente A Torres and Julio C. Tapia and Diego Andr{\'e}s Rodr{\'i}guez and Alvaro Lladser and Cristian A Arredondo and Lisette Leyton and Andrew F. G. Quest},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 21},
  pages={7703-17}
}
Caveolin-1 reportedly acts as a tumor suppressor and promotes events associated with tumor progression, including metastasis. The molecular mechanisms underlying such radical differences in function are not understood. Recently, we showed that caveolin-1 inhibits expression of the inhibitor of apoptosis protein survivin via a transcriptional mechanism involving the beta-catenin-Tcf/Lef pathway. Surprisingly, while caveolin-1 expression decreased survivin mRNA and protein levels in HT29(ATCC… CONTINUE READING