E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.

@article{Schmidt2005EcadherinIR,
  title={E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells.},
  author={Carl R Schmidt and Young Jin Gi and Trusharth A Patel and Robert J Coffey and Robert Daniel Beauchamp and A. Scott Pearson},
  journal={Surgery},
  year={2005},
  volume={138 2},
  pages={306-12}
}
BACKGROUND Loss of the cell membrane protein E-cadherin is a critical event during Ras-mediated transformation of intestinal epithelial cells. The purpose of our study is to determine if activation of the transcriptional repressor SLUG is an important component of the mechanism of Ras-induced loss of E-cadherin. METHODS Rat intestinal epithelial (RIE) cells were engineered to express mutated human Ha-Ras(Val12) complementary DNA (H-Ras cells). Cell morphology was examined by light microscopy… CONTINUE READING
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